Medline ® Abstract for Reference 11
of 'Treatment of acute exacerbations of multiple sclerosis in adults'
The bioavailability of IV methylprednisolone and oral prednisone in multiple sclerosis.
Morrow SA, Stoian CA, Dmitrovic J, Chan SC, Metz LM
Oral prednisone (1)might be a convenient, inexpensive alternative to IV methylprednisolone (IVMP) if the bioequivalent dose was known. We compared the total amount of steroid absorbed after 1250 mg oral prednisone vs 1 gram IVMP in 16 patients with multiple sclerosis (MS). At 24 hours, the mean area under the concentration-time curve (AUC), the main component of bioavailability, did not differ between groups (p = 0.122). This suggests that the amount of absorbed corticosteroid is similar after either steroid at these doses.
Department of Clinical Neurosciences, University of Western Ontario, London, Ontario, Canada.