Abstract
To compare the efficacy of high-dose intravenous methylprednisolone with intramuscular ACTH in the treatment of acute relapse in multiple sclerosis, we undertook a double-blind, randomized, controlled study involving 61 patients. There was a marked improvement in both groups in the course of the study, but no difference between them in either the rate of recovery or the final outcome. High-dose IV methylprednisolone is a safe alternative to ACTH in the management of acute relapse in MS.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
MeSH terms
-
Acute Disease
-
Adrenocorticotropic Hormone / administration & dosage*
-
Adrenocorticotropic Hormone / adverse effects
-
Adrenocorticotropic Hormone / therapeutic use
-
Adult
-
Clinical Trials as Topic
-
Female
-
Humans
-
Injections, Intramuscular
-
Injections, Intravenous
-
Male
-
Methylprednisolone / administration & dosage*
-
Methylprednisolone / adverse effects
-
Methylprednisolone / therapeutic use
-
Multiple Sclerosis / drug therapy*
-
Recurrence
Substances
-
Adrenocorticotropic Hormone
-
Methylprednisolone