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Treatment and prognosis of uterine leiomyosarcoma

Nadeem R Abu-Rustum, MD
Martee L Hensley, MD, MSc
Section Editors
Barbara Goff, MD
Don S Dizon, MD, FACP
Deputy Editors
Sadhna R Vora, MD
Sandy J Falk, MD, FACOG


Uterine leiomyosarcoma (LMS) is a rare uterine malignancy that arises from the smooth muscle of the uterine wall. Compared with other types of uterine cancers, LMS is an aggressive tumor associated with a high risk of recurrence and death, regardless of stage at presentation [1]. Tumor grade and other histologic features can influence clinical behavior of the tumors and may be important determinants of treatment recommendations. Whenever possible, women with uterine sarcomas should be referred to specialty centers with expertise in their diagnosis and management.  

This topic will cover the treatment approach to high-grade uterine LMS. The classification, clinical manifestations, diagnosis, and staging of other uterine sarcomas are covered separately. Treatment of other types of uterine sarcomas is also covered separately.

(See "Uterine sarcoma: Classification, clinical manifestations, and diagnosis".)

(See "Classification and treatment of endometrial stromal sarcoma and uterine adenosarcoma".)

(See "Clinical features, diagnosis, staging, and treatment of uterine carcinosarcoma".)

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Literature review current through: Oct 2017. | This topic last updated: Aug 23, 2017.
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