Thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS) are systemic disorders characterized by endothelial injury with small vessel platelet-rich thrombi that cause microangiopathic hemolytic anemia, thrombocytopenia, neurologic and/or renal abnormalities. The treatment of TTP-HUS in the adult will be discussed here.
Discussions of the causes and diagnosis of TTP-HUS in adults, and the diagnosis and treatment of HUS in children, are presented separately.
●(See "Causes of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in adults".)
●(See "Causes of thrombocytopenia in children".)
●(See "Diagnosis of thrombotic thrombocytopenic purpura-hemolytic uremic syndrome in adults".)