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Medline ® Abstracts for References 55-57

of 'Treatment and outcome of nausea and vomiting of pregnancy'

55
TI
Evaluation of the teratogenic effect of meclizine in man.
AU
Yerushalmy J, Milkovich L
SO
Am J Obstet Gynecol. 1965;93(4):553.
 
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PMID
56
TI
An evaluation of the teratogenicity of certain antinauseant drugs.
AU
Milkovich L, van den Berg BJ
SO
Am J Obstet Gynecol. 1976;125(2):244.
 
In a large, prospective, observational study of pregnancy and child development, the antinauseant drugs prescribed to gravides for nausea and vomiting in the first 84 days of pregnancy were evaluated for their teratogenic potential. The severe congenital anomaly rates per 100 liveborn children and ther perinatal death rates of this group did not differ from the rates of the group with untreated nausea and vomiting. There was no indication that the phenothiazine derivatives, specifically the prochlorperazine derivative, as well as meclizine, cylizine, and Bendectin were associated with teratogenicity. The trimethobenzamide drug gave a slight suggestion of an excess of severe congenital anomalies.
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PMID
57
TI
Meclizine in pregnancy in relation to congenital malformations.
AU
Shapiro S, Kaufman DW, Rosenberg L, Slone D, Monson RR, Siskind V, Heinonen OP
SO
Br Med J. 1978;1(6111):483.
 
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PMID