Medline ® Abstracts for References 16,17
of 'Treatment and outcome of nausea and vomiting of pregnancy'
Non-nutritional uses of vitamin B6.
Br J Nutr. 1999;81(1):7.
Vitamin B6 is a water-soluble vitamin, and is readily metabolized and excreted, so it has generally been assumed to have negligible toxicity, although at very high levels of intake it can cause peripheral nerve damage. Nutritional deficiency disease is extremely rare, although a significant proportion of the population shows biochemical evidence of inadequate status, despite apparently adequate levels of intake. The vitamin has been used to treat a wide variety of conditions, which may or may not be related to inadequate intake. In some conditions use of vitamin B6 supplements has been purely empirical; in other conditions there is a reasonable physiological or metabolic mechanism to explain why supplements of the vitamin many times greater than average requirements may have therapeutic uses. However, even in such conditions there is little evidence of efficacy from properly conducted controlled trials.
Department of Biochemistry and Molecular Biology, University College London, UK. firstname.lastname@example.org
Severe sensorimotor neuropathy after intake of highest dosages of vitamin B6.
Gdynia HJ, Müller T, Sperfeld AD, Kühnlein P, Otto M, Kassubek J, Ludolph AC
Neuromuscul Disord. 2008 Feb;18(2):156-8. Epub 2007 Dec 3.
We illustrate a white caucasian patient with a severe sensorimotor neuropathy due to vitamin B6 hypervitaminosis. The patient used the pendulum to calculate his daily metabolic demands and ingested 9.6g pyridoxine/day. To our knowledge, this is the highest dosage of vitamin B6 administered to humans over prolonged periods of time ever reported in the medical literature. The unique aspect of this case is the muscle weakness and motor findings on electrophysiological testing in what is suggested by the literature to be a pure sensory neuronopathy.
Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany. email@example.com