Medline ® Abstracts for References 153,154
of 'Treatment and outcome of nausea and vomiting of pregnancy'
Elective pregnancy termination in a large cohort of women with hyperemesis gravidarum.
Poursharif B, Korst LM, Macgibbon KW, Fejzo MS, Romero R, Goodwin TM
Contraception. 2007 Dec;76(6):451-5. Epub 2007 Nov 9.
BACKGROUND: This study was conducted to describe characteristics of women who terminated their pregnancies secondary to hyperemesis gravidarum (HG).
STUDY DESIGN: Data were obtained from a survey provided on an HG Web site from 2003 to 2005.
RESULTS: Of 808 women who completed the survey, 123 (15.2%) had at least one termination due to HG, and 49 (6.1%) had multiple terminations. Prominent reasons given for the terminations were inability to care for the family and self (66.7%), fear that they or their baby could die (51.2%), or that the baby would be abnormal (22.0%). These same women were three times as likely to state that their health care providers were uncaring or did not understand how sick they were [64/123 (52.0%) vs. 168/685 (24.5%), odds ratio 3.34 (95% CI 2.21-5.05), p<.001].
CONCLUSION: These data suggest that the physical and psychological burden of HG has been underestimated, and that further education within the medical community may be warranted.
Department of Obstetrics and Gynecology, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
Long-term neurodevelopment of children exposed to maternal nausea and vomiting of pregnancy and diclectin.
Nulman I, Rovet J, Barrera M, Knittel-Keren D, Feldman BM, Koren G
J Pediatr. 2009;155(1):45. Epub 2009 Apr 24.
OBJECTIVE: To determine the effects of nausea and vomiting of pregnancy (NVP) and its treatment with diclectin on child neurodevelopment.
STUDY DESIGN: An observational cohort study of mother-child pairs ascertained via a pregnancy call-in center was conducted. Three groups of children were studied: 45 with NVP and diclectin, 47 with NVP no diclectin, and 29 with no NVP. Phone calls to mothers during pregnancy and 6 to 9 months after childbirth yielded information on pregnancy, birth, and early child development. Children aged 3 to 7 years received a comprehensive set of psychological tests. Mothers were assessed for IQ and socioeconomic status.
RESULTS: All children scored in the normal range for IQ, with the NVP-exposed group scoring higher than the non-exposed group on Performance IQ (P<.02), NEPSY Verbal Fluency (P<.003) and Phonological Processing (P<.004), and McCarthy Numerical Memory (P<.004). Predictors of enhanced results were NVP severity and maternal IQ.
CONCLUSIONS: NVP has an enhancing effect on later child outcome. Diclectin does not appear to adversely affect fetal brain development and can be used to control NVP when clinically indicated.
Department of Clinical Pharmacology, Hospital for Sick Children, Toronto, Ontario, Canada. firstname.lastname@example.org