Medline ® Abstract for Reference 112
of 'Treatment and outcome of nausea and vomiting of pregnancy'
Hyperemesis gravidarum, nutritional treatment by nasogastric tube feeding: a 10-year retrospective cohort study.
Stokke G, Gjelsvik BL, Flaatten KT, Birkeland E, Flaatten H, Trovik J
Acta Obstet Gynecol Scand. 2015 Apr;94(4):359-67. Epub 2015 Feb 17.
OBJECTIVE: To investigate maternal and fetal outcome in hyperemesis gravidarum comparing enteral tube feeding of the mothers with other fluid/nutrition regimens.
DESIGN: Retrospective hospital-based cohort.
SETTING: University hospital, Norway.
SAMPLE: All 558 women treated for hyperemesis gravidarum 2002-2011; 273 received water/electrolytes intravenously, 177 received nutritional supplements by peripheral line, 107 received enteral feeding by gastroscopically positioned nasojejunal tube and 10 received total parenteral nutrition.
METHODS: Different fluid/nutritional groups were compared by chi-squared or non-parametric tests. The influence (odds ratio) of nutritional regimens on having small-for-gestational-age infants was evaluated by binary logistic regression.
MAIN OUTCOME MEASURES: Maternal weight gain during hospitalization and pregnancy, birthweight and gestational age at delivery.
RESULTS: Women receiving enteral nutrition had significantly greater weight loss on admission (median 5.0 kg) and at start of nutrition (5.5 kg) than the other treatment groups (4.0 kg) (p < 0.001). Enteral nutrition was administered for up to 41 days (median 5 days) during hospitalization, leading to 0.8 kg weight gain (95% CI 0.5-1.0, p = 0.005). The tube-fed women achieved similar weight gain during pregnancy and experienced similar incidence of preterm birth or small-for-gestational age compared with the other treatment groups. Women with<7 kg total weight gain had increased risk of birthweight<2500 g and small-for-gestational-age infants (odds ratio 3.68, 95% CI 1.89-7.18, p < 0.001). The nutritional regimen used was not an independent risk factor.
CONCLUSION: Compared with other fluid/nutrition regimens, enteral tube feeding for women affected by severe hyperemesis gravidarum is associated with adequate maternal weight gain and favorable pregnancy outcomes.
Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.