Transfusion-associated circulatory overload (TACO)
- Arthur J Silvergleid, MD
Arthur J Silvergleid, MD
- Section Editor — Transfusion Medicine
- Affiliate Associate Professor, Department of Pathology and Cell Biology
- University of South Florida, College of Medicine
- Medical Director, OneBlood, Inc.
Reactions to blood component transfusion can range from mild to potentially fatal. Transfusion-associated circulatory overload (TACO), also called transfusional volume overload, is a common transfusion reaction in which pulmonary edema develops primarily due to volume excess or circulatory overload. TACO typically occurs in patients who receive a large volume of a transfused product over a short period of time, or in those with underlying cardiovascular or renal disease.
This topic reviews the clinical manifestations, diagnosis, management, and prevention of TACO.
A general approach to a suspected transfusion reaction, as well as other specific reactions, are presented in detail separately:
●General approach – (See "Approach to the patient with a suspected acute transfusion reaction".)
●Transfusion-related acute lung injury (TRALI) – (See "Transfusion-related acute lung injury (TRALI)".)
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- PATHOPHYSIOLOGY AND RISK FACTORS
- CLINICAL PRESENTATION
- DIAGNOSTIC TESTING
- Evaluation and diagnosis
- Differential diagnosis
- - Transfusion reactions/TRALI
- - Heart failure
- - Pulmonary embolism
- Overview of prevention
- Transfusion rates
- Reducing RBC volume
- SUMMARY AND RECOMMENDATIONS