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Transcatheter mitral valve repair

Ehrin J Armstrong, MD, MSc, FACC
Elyse Foster, MD
Section Editor
William H Gaasch, MD
Deputy Editor
Susan B Yeon, MD, JD, FACC


Transcatheter mitral valve repair (TMVR) is a minimally invasive technique for treatment of symptomatic chronic moderate-severe or severe mitral regurgitation (MR).

This article reviews TMVR, with a focus on the indications for treatment, patient selection, outcomes, and complications using the MitraClip device. (See 'Available technology' below.)

An overview of management of chronic MR and surgical treatment of chronic MR are presented elsewhere. (See "Management of chronic primary mitral regurgitation" and "Surgical procedures for severe chronic mitral regurgitation".)


Mitral regurgitation (MR) can be caused by a primary disease of the valve leaflets (so-called primary MR, which is most commonly caused by "degenerative" or myxomatous mitral valve disease in developed countries), or by secondary (functional) causes such as by adverse left ventricular remodeling from cardiomyopathy or coronary artery disease. (See "Pathophysiology of chronic mitral regurgitation" and "Clinical manifestations and diagnosis of chronic mitral regurgitation".)


While a number of technologies are in clinical development, an edge-to-edge leaflet repair device (the MitraClip) is currently the only US Food and Drug Administration (FDA) approved device for TMVR. The MitraClip, as well as the CARILLON mitral annuloplasty device, has CE Mark approval. (See 'Investigational technologies' below.)

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Literature review current through: Nov 2017. | This topic last updated: Sep 15, 2017.
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