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Medline ® Abstract for Reference 86

of 'Toxicity of molecularly targeted antiangiogenic agents: Non-cardiovascular effects'

86
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Bowel perforation in non-small cell lung cancer after bevacizumab therapy.
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Schellhaas E, Loddenkemper C, Schmittel A, Buhr HJ, Pohlen U
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Invest New Drugs. 2009 Apr;27(2):184-7. Epub 2008 Jul 30.
 
BACKGROUND: Bevacizumab is increasingly used in combination with chemotherapy for treatment of unresectable non-small cell lung cancer. The aim of this report is to underline possible risks associated with this otherwise well-tolerated drug.
PATIENT: A 69-year-old patient with metastatic non-small cell lung cancer was started on a palliative chemotherapy regimen containing carboplatin, paclitaxel, and bevacizumab.
RESULTS: After the second cycle of chemotherapy, the patient developed abdominal pain. On emergency laparotomy, there was diffuse perforation of the colonic wall, so the patient underwent a Hartmann's procedure with subtotal colectomy. Histopathological examination confirmed the diagnosis of ischemic colitis.
CONCLUSION: Gastrointestinal perforation is a known adverse event of bevacizumab therapy which so far has occurred only in patients with predisposing risk factors. Our patient illustrates that there must always remain a high index of suspicion regarding bowel perforation in patients developing acute abdominal pain under bevacizumab therapy, even if they have no apparent risk factors.
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Chirurgische Klinik I, CharitéCampus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany. elisabeth.schellhaas@charite.de
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