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Medline ® Abstract for Reference 75

of 'Toxicity of molecularly targeted antiangiogenic agents: Non-cardiovascular effects'

Toxic dermatolysis, tissue necrosis and impaired wound healing due to sunitinib treatment leading to forefoot amputation.
Feyerabend S, Schilling D, Wicke C, Stenzl A
Urol Int. 2009;82(2):246-8. Epub 2009 Mar 19.
Innovative treatment strategies in urologic oncology confront the treating physician with a new spectrum of adverse events. With growing understanding of underlying pathomechanisms, we need to identify contraindications against the use of certain antiproliferative drugs. The management of toxicities involves a multidisciplinary approach and thus, the exchange of experience across medical specialties is mandatory. We report a case of fulminant toxic dermatolysis, tissue necrosis and impaired wound healing resulting in the amputation of one forefoot after 6 days of treatment with sunitinib.
Department of Urology, University of Tubingen, Tubingen, Germany.