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Medline ® Abstract for Reference 34

of 'Toxicity of molecularly targeted antiangiogenic agents: Non-cardiovascular effects'

Increased hemoglobin associated with VEGF inhibitors in advanced renal cell carcinoma.
Harshman LC, Kuo CJ, Wong BY, Vogelzang NJ, Srinivas S
Cancer Invest. 2009;27(8):851.
We retrospectively analyzed whether increased hemoglobin is a surrogate biomarker of efficacy for vascular endothelial growth factor (VEGF) inhibitors in advanced renal cell carcinoma (RCC) patients. Twelve patients were identified who had received bevacizumab alone or as combination therapy. Eleven patients experienced a rise in hemoglobin. Median change was 1.6 g/dL (0-4.0). Degree of peak increase correlated with longer progression-free survival (PFS) in metastatic patients: increase of<15% yielded a 3.1-month median PFS compared to 8.2 months with rises>15%. This study identifies increased hemoglobin as a possible consequence of VEGF inhibitors. The correlation with longer PFS suggests that rise in hemoglobin may be a surrogate biomarker of efficacy.
Stanford University School of Medicine, California 94305, USA. laurenhs@stanford.edu