Medline ® Abstract for Reference 145
of 'Toxicity of molecularly targeted antiangiogenic agents: Non-cardiovascular effects'
Sunitinib (sutent)-induced thyrotoxicosis due to destructive thyroiditis: a case report.
Faris JE, Moore AF, Daniels GH
Numerous drugs have been associated with destructive thyroiditis (subacute thyroiditis). Sunitinib, a tyrosine kinase inhibitor employed in renal cell carcinoma and gastrointestinal stromal tumors, has recently been linked to destructive thyroiditis with resultant hypothyroidism. We report a patient with transient overt thyrotoxicosis followed by hypothyroidism, apparently related to sunitinib therapy.
Department of Internal Medicine, Massachusetts General Hospital, 15 Parkman Street, Boston, MA 02114, USA.