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Medline ® Abstract for Reference 1

of 'Toxicities associated with checkpoint inhibitor immunotherapy'

Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies.
Naidoo J, Page DB, Li BT, Connell LC, Schindler K, Lacouture ME, Postow MA, Wolchok JD
Ann Oncol. 2015;26(12):2375. Epub 2015 Sep 14.
Immune checkpoint antibodies that augment the programmed cell death protein 1 (PD-1)/PD-L1 pathway have demonstrated antitumor activity across multiple malignancies, and gained recent regulatory approval as single-agent therapy for the treatment of metastatic malignant melanoma and nonsmall-cell lung cancer. Knowledge of toxicities associated with PD-1/PD-L1 blockade, as well as effective management algorithms for these toxicities, is pivotal in order to optimize clinical efficacy and safety. In this article, we review selected published and presented clinical studies investigating single-agent anti-PD-1/PD-L1 therapy and trials of combination approaches with other standard anticancer therapies, in multiple tumor types. We summarize the key adverse events reported in these studies and their management algorithms.
Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore jarushka_14@yahoo.com.