Medline ® Abstract for Reference 47
of 'Toll-like receptors: Roles in disease and therapy'
47
TI
Impaired T-cell receptor activation in IL-1 receptor-associated kinase-4-deficient patients.
AU
McDonald DR, Goldman F, Gomez-Duarte OD, Issekutz AC, Kumararatne DS, Doffinger R, Geha RS
SO
J Allergy Clin Immunol. 2010;126(2):332.
BACKGROUND:
IL-1 receptor-associated kinase 4 (IRAK-4) is an effector of the Toll-like receptor and IL-1 receptor pathways that plays a critical role in innate immune responses. The role of IRAK-4 in adaptive immune functions in human subjects is incompletely understood.
OBJECTIVE:
We sought to evaluate T-cell function in IRAK-4 deficient patients.
METHODS:
We compared upregulation of CD25 and CD69 on T cells and production of IL-2, IL-6, and IFN-gamma after stimulation of PBMCs from 4 IRAK-4-deficient patients and healthy control subjects with anti-CD3 and anti-CD28.
RESULTS:
Upregulation of CD25 and CD69 on T cells and production of IL-6 and IFN-gamma, but not IL-2, was significantly reduced in IRAK-4-deficient patients.
CONCLUSIONS:
IRAK-4-deficient patients have defects in T-cell activation.
AD
Division of Immunology, Children's Hospital, Boston, and the Department of Pediatrics, Harvard Medical School, Boston, Mass, USA.
PMID