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Medline ® Abstract for Reference 42

of 'Thyroid disorders and connective tissue disease'

Increased prevalence of anti-thyroid antibodies in patients with limited scleroderma.
Danielides S, Mavragani CP, Katsakoulas I, Zintzaras E, Drosos AA, Vlachoyiannopoulos PG, Moutsopoulos HM
Scand J Rheumatol. 2011;40(4):299-303. Epub 2011 Mar 21.
OBJECTIVES: Thyroid dysfunction in the setting of systemic sclerosis (SSc) has been described previously. We aimed to determine the prevalence of anti-thyroid antibodies (ATA) in a large SSc cohort and to ascertain whether they are associated with distinct clinical phenotypes.
METHODS: A total of 138 patients with SSc [46 with diffuse (dSSc) and 92 with limited scleroderma (lSSc)]and 100 healthy controls (HC) were tested for the presence of ATA [anti-thyroglobulin (anti-Tg) and anti-thyroid peroxidase (anti-TPO) antibodies]using a commercial enzyme-linked immunosorbent assay (ELISA). Clinical and serological data were recorded.
RESULTS: An increased prevalence of anti-TPO but not anti-Tg antibodies was detected in patients with SSc compared to HC (27.5% vs. 14%, p = 0.016). Of note, a statistically significant increase of anti-TPO was detected only in patients with lSSc compared to HC (32.6% vs. 14%, p = 0.003). No correlations with other clinical features were detected.
CONCLUSIONS: An increased prevalence of anti-TPO antibodies was identified in patients with lSSc. We propose that ATA testing should be offered to this subgroup of patients.
Department of Pathophysiology, School of Medicine, University of Athens, Athens, Greece. kmauragan@med.uoa.gr