Thromboembolism in children with cancer
- Uma H Athale, MD, MSc
Uma H Athale, MD, MSc
- Associate Professor of Pediatrics
- McMaster University
- Janet YK Yang, MBBS, MRCPCH
Janet YK Yang, MBBS, MRCPCH
- Clinical Fellow
- McMaster University
- Anthony KC Chan, MBBS, FRCPC, FRCPath
Anthony KC Chan, MBBS, FRCPC, FRCPath
- Professor of Pediatrics
- McMaster University, Canada
- Section Editors
- Alberto S Pappo, MD
Alberto S Pappo, MD
- Section Editor — Pediatric Oncology
- Head of Solid Malignancies Program
- St. Jude Children's Research Hospital
- Donald H Mahoney, Jr, MD
Donald H Mahoney, Jr, MD
- Section Editor — Pediatric Hematology
- Professor of Pediatrics
- Baylor College of Medicine
Children with cancer are at increased risk for thromboembolic events (TE) when compared with the general pediatric population. The following discussion will review the incidence, risk factors, evaluation, prevention, and management of TE in children with cancer.
The pathogenesis, clinical manifestations, diagnosis, and treatment of TE in the general pediatric population and newborns are discussed separately:
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- Acute lymphocytic leukemia (ALL)
- Acute myeloid leukemia and lymphoma
- Solid tumors
- Brain tumors
- CLINICAL MANIFESTATIONS
- EVALUATION AND DIAGNOSIS
- Choice of anticoagulant
- - LMWH dosing
- Asparaginase management
- - Antithrombin replacement therapy
- Asymptomatic right atrial thrombosis
- Primary prevention
- Recurrent thrombosis
- SUMMARY AND RECOMMENDATIONS