The treatment approach to non-clear cell renal carcinoma
- Toni K Choueiri, MD
Toni K Choueiri, MD
- Director, The Lank Center for Genitourinary Oncology
- Dana-Farber Cancer Institute and Brigham and Women's Hospital
- Associate Professor of Medicine
- Harvard Medical School
- Sumanta K Pal, MD
Sumanta K Pal, MD
- Assistant Professor, Department of Medical Oncology & Experimental Therapeutics
- City of Hope Comprehensive Cancer Center
Although many advances have been made in the treatment of metastatic renal cell carcinoma (mRCC), the majority of studies to date have been limited to patients with a component of clear cell disease . Due to the infrequency of non-clear cell RCC, there is a paucity of high-quality data to help inform the management of these tumors.
This topic will discuss the management of non-clear cell RCC. The epidemiology, pathology, and pathogenesis of these tumors are discussed separately, as is the treatment of clear cell RCC. (See "Epidemiology, pathology, and pathogenesis of renal cell carcinoma" and "Overview of the treatment of renal cell carcinoma".)
SUBTYPES OF NON-CLEAR CELL RENAL CELL CARCINOMA
Non-clear cell renal cell carcinomas (RCCs) are characterized by morphology, growth pattern, cell of origin, and where it is known, by the histochemical and biologic bases that underlie the different types of tumors. The main subtypes of non-clear cell RCC include (see "Epidemiology, pathology, and pathogenesis of renal cell carcinoma", section on 'Pathology'):
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- SUBTYPES OF NON-CLEAR CELL RENAL CELL CARCINOMA
- OVERVIEW OF TREATMENT
- TREATMENT APPROACH BY HISTOLOGIC SUBTYPE
- Papillary renal cell carcinoma
- RCC with sarcomatoid features
- Chromophobe RCC
- Collecting duct RCC
- Renal medullary carcinoma
- Translocation renal cell carcinoma
- SUMMARY AND RECOMMENDATIONS