Medline ® Abstract for Reference 74
of 'The ketogenic diet and other dietary therapies for the treatment of epilepsy'
74
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Intermittent fasting: a "new" historical strategy for controlling seizures?
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Hartman AL, Rubenstein JE, Kossoff EH
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Epilepsy Res. 2013 May;104(3):275-9. Epub 2012 Dec 1.
In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.
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Department of Neurology, Johns Hopkins Medicine, 600N. Wolfe St., Meyer 2-147, Baltimore, MD 21287, United States. ahartma2@jhmi.edu
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