Medline ® Abstract for Reference 63
of 'The ketogenic diet and other dietary therapies for the treatment of epilepsy'
63
TI
Concomitant lamotrigine use is associated with decreased efficacy of the ketogenic diet in childhood refractory epilepsy.
AU
van der Louw EJ, Desadien R, Vehmeijer FO, van der Sijs H, Catsman-Berrevoets CE, Neuteboom RF
SO
Seizure. 2015;32:75. Epub 2015 Sep 21.
PURPOSE:
Anti-epileptic drugs (AEDs) and the ketogenic diet (KD) are often used concomitantly in children with refractory epilepsy. It has been hypothesised that certain AEDs may interfere with KD. The purpose of this study was to elucidate relationships between efficacy of KD and use of specific AEDs.
METHODS:
A retrospective study was performed in 71 children with refractory epilepsy starting the KD between 2008 and 2014 in Erasmus University Hospital Sophia Children's Hospital. Efficacy of the KD (defined as 50% seizure reduction) was evaluated after three months of treatment and related to the AEDs used.
RESULTS:
The KD was successful after three months in 61% of the children (N=71). Efficacy was significantly reduced if children (n=16) used lamotrigine (31%) at diet initiation or in the course of the diet, compared to other antiepileptic drugs (69%) (p=0.006). In comparison to children using other antiepileptic drugs, the percentage of children that had adequate ketosis was significantlyreduced in case of lamotrigine use (p=0.049).
CONCLUSION:
Lamotrigine treatment during KD is associated with a decreased efficacy of the KD.
AD
Department of Dietetics, Erasmus University Hospital Sophia Children's Hospital, Rotterdam, The Netherlands. Electronic address: e.vanderlouw@erasmusmc.nl.
PMID