The incompatible crossmatch
- Dennis Goldfinger, MD
Dennis Goldfinger, MD
- Professor, Division of Transfusion Medicine David Geffen School of Medicine at UCLA
- Dawn Ward, MD
Dawn Ward, MD
- Assistant Professor, Division of Transfusion Medicine
- David Geffen School of Medicine at UCLA
An essential goal in transfusion medicine is that transfused blood be compatible with the patient. The clinical and serologic evaluation, which allows for the transfusion of the most compatible (or "least incompatible") blood, requires a joint effort between the clinician and the transfusion medicine physician .
However, there are times when all available resources are exhausted and a unit of blood that is not crossmatch compatible must be issued to the patient. The most common of these clinical situations as well as suggestions on how safely to issue and transfuse the best unit of blood available will be reviewed here. General discussions of crossmatching procedures and red cell antigens are presented separately. (See "Pretransfusion testing for red blood cell transfusion" and "A primer of red blood cell antigens and antibodies".)
When blood is ordered for transfusion, a sample of blood is obtained from the patient, and the transfusion service typically performs type and screen and crossmatching tests on the patient's red blood cells (RBCs) and plasma:
●A type test of the patient's RBCs to determine the ABO and Rh types. (See "Pretransfusion testing for red blood cell transfusion", section on 'Antibody screen'.)
●An antibody screen of the patient's plasma to determine if unexpected anti-RBC antibodies are present.
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- CROSSMATCHING OVERVIEW
- INITIAL EVALUATION AND MANAGEMENT
- Communication between clinical team and transfusion team
- Patient history
- Immediate management
- Common alloantibodies
- - Alloantibody persistence and evanescence
- Multiple alloantibodies
- - Sickle cell disease
- Alloantibodies to high frequency antigens
- Delayed hemolytic transfusion reaction
- Identification of blood for transfusion
- - Patients with multiple alloantibodies
- - Alloantibody to a high frequency antigen
- Warm autoimmune hemolytic anemia
- Cold agglutinin disease
- Drug-induced AIHA
- AIHA and concurrent alloantibodies
- Identification of blood for transfusion
- In vivo crossmatch
- ABO DISCREPANCIES