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The epidemiology and pathogenesis of pulmonary arterial hypertension (Group 1)

Lewis J Rubin, MD
William Hopkins, MD
Section Editors
Jess Mandel, MD
Andrew Nicholson, MD
Deputy Editor
Geraldine Finlay, MD


Pulmonary hypertension (PH) is a disease characterized by elevated pulmonary artery pressure (mean pulmonary artery pressure ≥25 mmHg at rest). The World Health Organization (WHO) classifies patients with PH into five groups (table 1) based upon etiology [1]:

Group 1 – Pulmonary arterial hypertension (PAH)

Group 2 – PH due to left heart disease

Group 3 – PH due to chronic lung disease and/or hypoxemia

Group 4 – Chronic thromboembolic pulmonary hypertension (CTEPH)

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Literature review current through: Dec 2017. | This topic last updated: Nov 28, 2017.
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