Medline ® Abstract for Reference 64
of 'Taxane-induced pulmonary toxicity'
Fatal interstitial pneumonitis associated with docetaxel administration in a patient with hormone-refractory prostate cancer.
Leimgruber K, Negro R, Baier S, Moser B, Resch G, Sansone S, Adami M, Zanon P, Graiff C, Egarter-Vigl E, Wiedermann CJ
Tumori. 2006 Nov-Dec;92(6):542-4.
Taxanes are widely used chemotherapeutic agents with the potential to induce pulmonary injury through a variety of mechanisms. Patients receiving these agents are at risk of acute or subacute pulmonary damage. The case is presented of a 72-year-old man with hormone-refractory prostate cancer and weekly administration of 30 mg/m2 docetaxel who developed subacute interstitial pneumonitis-related pulmonary fibrosis after seven doses and died despite mechanical ventilation and high-dose corticosteroid treatment. Even though only a few cases of this adverse event have been reported in the literature, severe docetaxel-induced pulmonary toxicity needs to be considered in the differential diagnosis when such patients present with respiratory symptoms.
Departments of Internal Medicine,S. Maurizio Central Hospital of Bolzano, Bolzano, Italy.