T-cell targeted therapies for rheumatoid arthritis
- Vibeke Strand, MD
Vibeke Strand, MD
- Clinical Professor (Adjunct)
- Stanford University School of Medicine
- Edward Keystone, MD
Edward Keystone, MD
- Professor of Medicine
- Mount Sinai Hospital, University of Toronto
- Section Editor
- Ravinder N Maini, BA, MB BChir, FRCP, FMedSci, FRS
Ravinder N Maini, BA, MB BChir, FRCP, FMedSci, FRS
- Section Editor — Rheumatoid Arthritis
- Emeritus Professor of Rheumatology, Imperial College London
- Visiting Professor, Oxford University
The rationale for using T-cell targeted therapies for the treatment of rheumatoid arthritis (RA) stems from data that highlight the role of T cells in disease pathogenesis [1,2]. (See "Pathogenesis of rheumatoid arthritis".)
The data include:
●Animal models of inflammatory arthritis that demonstrate a crucial role for antigen-specific CD4+ T cells.
●The presence of an intense CD4+ T-cell infiltrate within rheumatoid synovium.
●The association between the inheritance of certain major histocompatibility complex (MHC) class II alleles and the development of RA. MHC class II alleles are required for antigen presentation to T cells. (See "HLA and other susceptibility genes in rheumatoid arthritis".)
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