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T-cell targeted therapies for rheumatoid arthritis

Authors
Vibeke Strand, MD
Edward Keystone, MD
Section Editor
Ravinder N Maini, BA, MB BChir, FRCP, FMedSci, FRS
Deputy Editor
Paul L Romain, MD

INTRODUCTION

The rationale for using T-cell targeted therapies for the treatment of rheumatoid arthritis (RA) stems from data that highlight the role of T cells in disease pathogenesis [1,2]. (See "Pathogenesis of rheumatoid arthritis".)

The data include:

Animal models of inflammatory arthritis that demonstrate a crucial role for antigen-specific CD4+ T cells.

The presence of an intense CD4+ T-cell infiltrate within rheumatoid synovium.

The association between the inheritance of certain major histocompatibility complex (MHC) class II alleles and the development of RA. MHC class II alleles are required for antigen presentation to T cells. (See "HLA and other susceptibility genes in rheumatoid arthritis".)

           

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Literature review current through: Nov 2016. | This topic last updated: Mon Sep 28 00:00:00 GMT+00:00 2015.
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