Although metastatic breast cancer is unlikely to be cured, meaningful improvements in survival have been seen, coincident with the introduction of newer systemic therapies [1-3]. Median overall survival approaches two years, with a range from a few months to many years .
The selection of a therapeutic strategy depends upon both tumor biology and clinical factors, with the goal being a tailored approach. Although a subset of patients with oligometastatic disease may benefit from an intensified locoregional approach, most patients with metastatic breast cancer receive systemic medical therapy, consisting of chemotherapy, endocrine therapy, and/or biologic therapies, and supportive care measures [5,6].
The efficacy and dosing of single agent chemotherapy is presented here. General principles of management of metastatic breast cancer, selection of chemotherapy regimen, and use of combination chemotherapy, biologics therapies, endocrine therapy, surgical options, and supportive care are discussed separately.
Treatment principles for the use of chemotherapy in metastatic breast cancer are outlined here.