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Medline ® Abstract for Reference 75

of 'Systemic treatment for metastatic breast cancer: General principles'

75
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Review of local soft tissue recurrence of breast cancer irradiated with and without actinomycin-D.
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Olson CE, Ansfield FJ, Richards MJ, Ramirez G, Davis HL
SO
Cancer. 1977;39(5):1981.
 
Between 1962 and 1973, regionally recurrent breast cancer was treated in 156 patients by irradiation alone or irradiation with concurrent actinomycin-D. Thirty-two patients were entered into a randomized trial, and 124 patients were retrospectively reviewed. Local control with irradiation alone was achieved in 48 of 80 patients (60%) and in 60 of 76 patients (79%) treated with irradiation and actinomycin-D (p less than .05). Results were remarkably similar in the randomized and retrospective series.
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PMID