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Systemic mastocytosis: Determining the category of disease

Mariana C Castells, MD, PhD
Cem Akin, MD, PhD
Section Editor
Bruce S Bochner, MD
Deputy Editor
Anna M Feldweg, MD


Mastocytosis describes a group of disorders in which pathologic mast cells accumulate in tissues. In systemic mastocytosis (SM), mast cells infiltrate extracutaneous tissues. Once the diagnosis of SM has been reached, the category of disease must be determined, as treatment and prognosis differ for each disorder.

Topics related to other aspects of mastocytosis are found separately:

(See "Mastocytosis (cutaneous and systemic): Evaluation and diagnosis in adults".)

(See "Mastocytosis (cutaneous and systemic): Evaluation and diagnosis in children".)

(See "Mastocytosis (cutaneous and systemic): Epidemiology, pathogenesis, and clinical manifestations".)


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Literature review current through: Sep 2016. | This topic last updated: Dec 18, 2015.
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