Medline ® Abstract for Reference 30
of 'Systemic chemotherapy for nonoperable metastatic colorectal cancer: Treatment recommendations'
Concordant KRAS mutations in primary and metastatic colorectal cancer tissue specimens: a meta-analysis and systematic review.
Han CB, Li F, Ma JT, Zou HW
Cancer Invest. 2012;30(10):741. Epub 2012 Oct 17.
A meta-analysis was performed to compare KRAS gene mutations in colorectal cancer tissue samples with primary and metastatic colorectal cancers. A total of 19 publications with 986 paired primary and distant metastases and 171 paired primary and lymph node metastases showed that KRAS genotype was highly concordant in primary and distant metastatic tumors, indicating that either type of tumor tissue could be useful as a source to detect KRAS mutations for selection of anti-EGFR therapy. However, lymph-node-metastatic tumors might not be suitable for diagnostic analysis of KRAS mutations due to an obvious discordant rate between primary and lymph-node-metastatic tumors.
Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, China.