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Medline ® Abstract for Reference 218

of 'Systemic chemotherapy for metastatic colorectal cancer: Completed clinical trials'

Meta-analysis of incidence and risk of hypokalemia with cetuximab-based therapy for advanced cancer.
Cao Y, Liu L, Liao C, Tan A, Gao F
Cancer Chemother Pharmacol. 2010;66(1):37. Epub 2009 Sep 17.
PURPOSE: To gain a better understanding of the incidence and risk of hypokalemia in patients who received cetuximab-based therapy.
PATIENTS AND METHODS: Databases, including Pubmed, EMBASE, The Cochrane Library, annual meeting of American Society of Clinical Oncology (2000-2008), and Web of science were searched to identify relevant studies. Eligible studies were prospective phase II-III clinical trials of patients with cancer assigned cetuximab at the dose of 400 mg/m(2) IV on day 1 and 250 mg/m(2) weekly thereafter. The primary endpoint was incidence of hypokalemia.
RESULTS: Eleven clinical reports were identified which included a total of 2,254 patients who were available for analysis, with 1,324 patients assigned cetuximab-based treatment. The results showed high incidence of grade 3 and 4 hypokalemia [6.2% (95% CI 4.9-7.7)]and high incidence of all-grade hypokalemia [8.0% (95% CI 4.5-13.9)]associated with cetuximab-based therapy for advanced cancer. Compared with non-cetuximab therapy, cetuximab-based therapy has higher risk of grade 3 and 4 hypokalemia [1.81 (95% CI 1.12-2.93)].
CONCLUSION: Cetuximab-based therapy is associated with a significant risk of hypokalemia. Early monitoring and effective management of hypokalemia is important for patients that received cetuximab-based therapy.
Department of Colorectal and Anal Surgery, First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People's Republic of China.