Syphilis in pregnancy
- Errol R Norwitz, MD, PhD, MBA
Errol R Norwitz, MD, PhD, MBA
- Professor and Chair
- Department of Obstetrics and Gynecology
- Tufts Medical Center and Tufts University School of Medicine
- Charles B Hicks, MD
Charles B Hicks, MD
- University of California, San Diego
- Section Editors
- Charles J Lockwood, MD, MHCM
Charles J Lockwood, MD, MHCM
- Section Editor — Obstetrics
- Senior Vice President, USF Health
- Dean, Morsani College of Medicine
- Professor, Obstetrics and Gynecology
- University of South Florida
- John G Bartlett, MD
John G Bartlett, MD
- Editor-in-Chief — Infectious Diseases
- Section Editor — HIV; Pulmonary Infections
- Professor Emeritus
- Johns Hopkins University School of Medicine
- Deputy Editors
- Vanessa A Barss, MD, FACOG
Vanessa A Barss, MD, FACOG
- Senior Deputy Editor — UpToDate
- Deputy Editor — Obstetrics, Gynecology and Women's Health
- Associate Clinical Professor of Obstetrics, Gynecology and Reproductive Biology
- Harvard Medical School
- Jennifer Mitty, MD, MPH
Jennifer Mitty, MD, MPH
- Deputy Editor — Infectious Diseases
Syphilis is a systemic infection caused by the spirochete Treponema pallidum, which is of particular concern during pregnancy because of the risk of transplacental infection of the fetus. Congenital infection is associated with several adverse outcomes [1-7], including:
●Low birth weight
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- INCIDENCE AND EPIDEMIOLOGY
- CLINICAL FINDINGS
- Primary syphilis
- Secondary syphilis
- Tertiary syphilis
- Latent syphilis
- MATERNAL SCREENING
- Candidates and timing
- Concurrent HIV screening
- False positives and false negatives
- PERINATAL TRANSMISSION
- Risk factors
- Pregnancy outcome
- Congenital syphilis
- - Placental findings
- - Fetal findings
- - Infant findings
- MATERNAL TREATMENT
- Preferred regimen: penicillin
- Use of alternative regimens
- Patients allergic to penicillin
- - Skin testing
- - Desensitization
- Jarisch-Herxheimer reaction
- Following titers after treatment
- OBSTETRICAL ISSUES
- SOCIETY GUIDELINE LINKS
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS