Syphilis in pregnancy
- Errol R Norwitz, MD, PhD
Errol R Norwitz, MD, PhD
- Professor and Chair
- Department of Obstetrics and Gynecology
- Tufts Medical Center and Tufts University School of Medicine
- Section Editors
- Charles J Lockwood, MD, MHCM
Charles J Lockwood, MD, MHCM
- Section Editor — Obstetrics
- Senior Vice President, USF Health
- Dean, Morsani College of Medicine
- Professor, Obstetrics and Gynecology
- University of South Florida
- John G Bartlett, MD
John G Bartlett, MD
- Editor-in-Chief — Infectious Diseases
- Section Editor — HIV; Pulmonary Infections
- Professor Emeritus
- Johns Hopkins University School of Medicine
Syphilis is a systemic infection caused by the spirochete Treponema pallidum, which is of particular concern during pregnancy because of the risk of transplacental infection of the fetus. Congenital infection is associated with several adverse outcomes [1-7], including:
●Low birth weight
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- INCIDENCE AND EPIDEMIOLOGY
- CLINICAL MANIFESTATIONS
- Primary syphilis
- Secondary syphilis
- Latent syphilis
- Tertiary syphilis
- MATERNAL SCREENING
- Direct visualization
- Standard serologic testing
- - False positives
- Cerebrospinal fluid examination
- PERINATAL TRANSMISSION
- Risk factors
- Pregnancy outcome
- Congenital syphilis
- - Placental findings
- - Fetal findings
- - Infant findings
- MATERNAL TREATMENT
- Penicillin allergy
- - Skin testing
- - Desensitization
- Jarisch-Herxheimer reaction
- Following titers after treatment
- OBSTETRICAL ISSUES
- INFORMATION FOR PATIENTS
- SUMMARY AND RECOMMENDATIONS