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Medline ® Abstract for Reference 30

of 'Surgical resection of sporadic pancreatic neuroendocrine tumors'

Surgery on neuroendocrine tumours.
Akerström G, Hellman P
Best Pract Res Clin Endocrinol Metab. 2007 Mar;21(1):87-109.
Neuroendocrine tumours of the gastrointestinal tract and pancreas present a major challenge to physicians in their recognition and treatment requirements, and surgical treatment of these tumours has become increasingly important for symptom palliation and survival. For some carcinoid tumours the extent of surgery may depend on tumour size. Midgut carcinoid is the most common cause of the carcinoid syndrome, requiring surgery for primary and mesenteric tumours to minimize the risk for abdominal complications but also for removal of liver metastases to palliate hormonal symptoms. Among endocrine pancreatic tumours, insulinoma and gastrinoma often cause severe symptoms of hormone excess despite their inconspicuous size, but they can be successfully removed with improved pre- and intraoperative localization. Other tumours--glucagonoma, VIPoma, and non-functioning endocrine pancreatic tumours--are often large or metastasizing, but generally require surgical debulking to alleviate hormonal symptoms and have favourable survival.
Department of Surgical Sciences, University Hospital, SE-751 85 Uppsala, Sweden. goran.akerstrom@surgsci.uu.se