Medline ® Abstracts for References 1,2
of 'Surgical resection of sporadic pancreatic neuroendocrine tumors'
Pancreatic neuroendocrine tumors (PNETs): incidence, prognosis and recent trend toward improved survival.
Halfdanarson TR, Rabe KG, Rubin J, Petersen GM
Ann Oncol. 2008;19(10):1727. Epub 2008 May 30.
BACKGROUND: Pancreatic neuroendocrine tumors (PNETs) are uncommon neoplasms that can present with symptoms of hormone overproduction. We evaluated the incidence, prognosis, and temporal trends of PNETs.
PATIENTS AND METHODS: We analyzed all cases of PNETs registered in the Surveillance, Epidemiology, and End Results database from 1973 to 2000. Age-adjusted incidence and survival rates were calculated and survival trends over time were evaluated.
RESULTS: We identified 1483 cases of PNETs. The crude annual incidence per 1,000,000 was 1.8 in females and 2.6 in males and increased with advancing age. The incidence increased over the study period. Most patients (90.8%) had nonfunctional tumors. Advanced stage, higher grade, and age were the strongest predictors of worse survival. Patients with functional tumors had better outcomes than patients with nonfunctional tumors in both univariate and multivariate analysis (P = 0.004). Survival time increased over the period from 1973 to 2000. No differences were seen in the distribution of stage or age at diagnosis among time periods.
CONCLUSION: PNETs are uncommon neoplasms but the incidence may be increasing. Age, grade, stage, and functional status predict survival in patients with PNETs. Survival has improved over time, but this is not explained by earlier diagnosis or stage migration.
Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, MN, USA. email@example.com
Pancreatic endocrine neoplasms: epidemiology and prognosis of pancreatic endocrine tumors.
Halfdanarson TR, Rubin J, Farnell MB, Grant CS, Petersen GM
Endocr Relat Cancer. 2008;15(2):409.
Pancreatic endocrine tumors (PETs) are uncommon tumors with an annual incidence<1 per 100 000 person-years in the general population. The PETs that produce hormones resulting in symptoms are designated as functional. The majority of PETs are non-functional. Of the functional tumors, insulinomas are the most common, followed by gastrinomas. The clinical course of patients with PETs is variable and depends on the extent of the disease and the treatment rendered. Patients with completely resected tumors generally have a good prognosis, and aggressive surgical therapy in patients with advanced disease may also prolong survival. The epidemiology, prognosis, and established and novel prognostic markers of PETs are reviewed.
Division of Oncology, Department of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. firstname.lastname@example.org