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Medline ® Abstract for Reference 113

of 'Surgical resection of lesions of the body and tail of the pancreas'

The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial.
Sarr MG, Pancreatic Surgery Group
J Am Coll Surg. 2003 Apr;196(4):556-64; discussion 564-5; author reply 565.
BACKGROUND: Pancreatectomy can be complicated by pancreatic anastomotic leakage, causing major morbidity.
STUDY DESIGN: Our aim was to determine if vapreotide, a potent long-acting somatostatin analogue, would decrease pancreas-related complications. This prospective, multicenter, randomized, double-blind, placebo-controlled trial involved 275 patients without preexisting chronic pancreatitis undergoing elective proximal, central, or distal pancreatectomy. Complications were defined by objective criteria before beginning the study.
RESULTS: One hundred thirty-five patients received vapreotide; 140 patients received placebo. There were no statistically significant differences between vapreotide- and placebo-treated patients in either pancreas-related complications (30.4% versus 26.4%, respectively) or in other complications not directly related to the pancreas (40% versus 42%, respectively).
CONCLUSIONS: The potent somatostatin analogue vapreotide does not appear to decrease postoperative complications after major pancreatectomy in patients without chronic pancreatitis.
Gastroenterology Research Unit (AL 2-436), Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.