Medline ® Abstract for Reference 81
Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management.
Lim S, Katz K, Krajden S, Fuksa M, Keystone JS, Kain KC
Strongyloidiasis, which is caused by the nematode Strongyloides stercoralis, is a common and persistent infection, particularly in developing countries. In the setting of compromised cellular immunity, it can result in fulminant dissemination with case-fatality rates of over 70%. The majority of new Canadian immigrants come from countries where Strongyloides is highly endemic; therefore, the burden of Strongyloides may be underappreciated in Canada. Because early diagnosis and therapy can have a marked impact on disease outcome, screening for this infection should be considered mandatory for patients who have a history of travel or residence in a disease-endemic area and risk factors for disseminated disease (e.g., corticosteroid use and human T-lymphotropic virus type I infection).
Tropical Disease Unit, Division of Infectious Diseases, Department of Medicine, University of Toronto, Toronto General Hospital--University Health Network, Toronto, Ont.