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Medline ® Abstract for Reference 69

of 'Strongyloidiasis'

69
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Strongyloides hyperinfection and hypogammaglobulinemia.
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Seet RC, Lau LG, Tambyah PA
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Clin Diagn Lab Immunol. 2005;12(5):680.
 
We report strongyloides hyperinfection in two patients with generalized hypogammaglobulinemia from multiple myeloma and nephrotic syndrome, despite a significant strongyloides-specific immunoglobulin G (IgG) response. In contrast to reports on animals, where human IgG was shown to be a protective antibody, our observation suggests that in humans, immunity to the infective-stage larvae is not protective against the autoinfective larvae, which are the causative agents of strongyloides hyperinfection.
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Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074. raymond_seet@nus.edu.sg
PMID