Medline ® Abstract for Reference 18
Immunoepidemiologic studies of Strongyloides stercoralis and human T lymphotropic virus type I infections in Jamaica.
Robinson RD, Lindo JF, Neva FA, Gam AA, Vogel P, Terry SI, Cooper ES
J Infect Dis. 1994;169(3):692.
Epidemiologic investigations of Strongyloides stercoralis and human T lymphotropic virus type I (HTLV-I) infections were conducted. Of 312 persons contacted, 209 (67%) provided blood and stool samples. Prevalences of S. stercoralis and HTLV-I antibodies were 26.8% and 8.1% (n = 198), respectively, and S. stercoralis larvae were detected in 4%. HTLV-I antibodies were significantly more common in persons positive for S. stercoralis larvae (10 [58.8%]of 17) compared with seropositive larva-negative (4 [8.9%]of 45) or seronegative persons (9 [6.2%]of 145) (P<.002). IgE levels increased with age in S. stercoralis-seropositive persons who were HTLV-I negative (P<.002). However, there was an age-related depression of serum IgE in HTLV-I-positive positive persons (P<.003) that was sufficient to annul the IgE level-raising effect of S. stercoralis seropositivity. The data provide evidence that HTLV-I infection is associated with increased frequency of larvae in the stool of S. stercoralis-infected persons and suggest that the mechanism may involve suppression of the IgE response.
Department of Zoology, University of the West Indies, Kingston, Jamaica.