Medline ® Abstract for Reference 55
of 'Stevens-Johnson syndrome and toxic epidermal necrolysis: Pathogenesis, clinical manifestations, and diagnosis'
55
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Stevens-Johnson syndrome/toxic epidermal necrolysis in a patient receiving concurrent radiation and gemcitabine.
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Sommers KR, Kong KM, Bui DT, Fruehauf JP, Holcombe RF
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Anticancer Drugs. 2003;14(8):659.
A patient with stage IV malignant melanoma treated with daily radiotherapy and low-dose (100 mg/m2) daily gemcitabine developed a blistering skin eruption, fever and neutropenia consistent with overlap Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). The diagnosis was confirmed by skin biopsy of an affected area. The case history is described, and the literature relating to the development of SJS/TEN in association with chemotherapy and radiotherapy administration is reviewed. This report describes a serious potential complication of concurrent gemcitabine and radiotherapy.
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Division of Hematology/Oncology, University of California and Chao Family Comprehensive Cancer Center, Irvine, CA, USA.
PMID