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Medline ® Abstract for Reference 8

of 'Small cell carcinoma of the bladder'

Small cell carcinoma of the urinary bladder. Presentation of 23 cases and review of 134 published cases.
Trias I, Algaba F, Condom E, Español I, SeguíJ, Orsola I, Villavicencio H, García Del Muro X
Eur Urol. 2001;39(1):85.
OBJECTIVE: To investigate the morphological diagnostic criteria and biology of the urinary bladder small cell carcinoma (SCC).
METHODS: Study of 23 cases of bladder SCC, looking for the clinical presentation, pathological features and evolution, and review of 134 previously published cases.
RESULTS: The SCC is infrequent (0.48-1%), 50% of them have areas of transitional cell carcinoma, supporting the metaplastic theory. The classic small cell morphology is the best diagnostic criterion. The neurone-specific enolase and chromogranin A are good markers, but not indispensable. An early metastatic incidence (56%) with a high mortality rate (68.7%), mostly before 2 years after the diagnosis, is the typical evolution. Only the patients with additional cis-platinum-based chemotherapy have better prognosis.
CONCLUSION: The pathologist should watch out for the presence of SCC and the urologist should consider the possibility of combined treatment for these cases.
Department of Pathology, Clínica Plató, FundacióPrivada, Barcelona, Spain.