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Medline ® Abstract for Reference 33

of 'Sleepwalking and other parasomnias in children'

33
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REM behavior disorder (RBD) can be one of the first symptoms of childhood narcolepsy.
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Nevsimalova S, Prihodova I, Kemlink D, Lin L, Mignot E
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Sleep Med. 2007 Nov;8(7-8):784-6. Epub 2007 Jun 13.
 
More than one in three adult patients suffering from narcolepsy-cataplexy experience rapid eye movement (REM) behavior disorder (RBD), while RBD in childhood is extremely rare. We present the cases of two girls (aged 9 and 7 years old) with narcolepsy-cataplexy, in whom RBD was one of the first symptoms of the disease. The coincidence of RBD was seen by nocturnal video-polysomnography (v-PSG), and narcolepsy was diagnosed from short sleep latency and multiple sleep onset REMs (SOREMs) during a multiple sleep latency test (MSLT). Both girls were human leukocyte antigen (HLA)-DQB1 *0602 positive, and their cerebrospinal fluid (CSF) hypocretin level (Hcrt-1) was extremely low.
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Department of Neurology, 1st Medical Faculty, Charles University, Prague, Czech Republic. snevsi@lfl1.cuni.cz
PMID