Medline ® Abstract for Reference 2
of 'Sideline evaluation of concussion'
Pathophysiology of Sports-Related Concussion.
Steenerson K, Starling AJ
Neurol Clin. 2017;35(3):403. Epub 2017 May 30.
Concussion pathophysiology is complicated and involves numerous mechanisms, including excessive neurotransmitter release, metabolic derangements, neuroinflammation, cerebral blood flow changes, and axonal disruption. The initial biomechanical impact in a concussion results in abnormal function at the cellular level, which initiates a cascade of events that leads to microstructural changes and, in the minority of cases, more persistent, permanent damage.
Neurology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, Arizona 85013, USA.