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Serotonin modulators: Pharmacology, administration, and side effects

Michael Hirsch, MD
Robert J Birnbaum, MD, PhD
Section Editor
Peter P Roy-Byrne, MD
Deputy Editor
David Solomon, MD


Advances in understanding brain neurophysiology have led to the development of serotonin modulators, including [1]:




The serotonin modulators are distinct from other classes of antidepressants that include selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), atypical antidepressants, tricyclics, and monoamine oxidase inhibitors (MAOIs). Serotonin modulators antagonize postsynaptic serotonin receptors and inhibit reuptake of postsynaptic serotonin to varying degrees; effects upon norepinephrine reuptake are minimal.


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