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Selecting an antiretroviral regimen for treatment-experienced HIV-infected patients who are failing therapy

Eric S Daar, MD
Section Editor
John G Bartlett, MD
Deputy Editor
Jennifer Mitty, MD, MPH


The standard of care in HIV management is to maximally suppress plasma HIV RNA to prevent HIV disease progression and the emergence of drug-resistant virus. Achieving virologic suppression can be difficult for HIV-infected patients with drug-resistant virus; however, advances in drug development have enabled great progress in the treatment of this patient population.

The selection of combination antiretroviral therapy (ART) for the treatment-experienced patient who is failing therapy is discussed here. The selection of ART for the treatment-naïve patient and the initial evaluation of the treatment-experienced patient failing therapy are discussed elsewhere. (See "Selecting antiretroviral regimens for the treatment-naïve HIV-infected patient" and "Evaluation of the treatment-experienced patient failing HIV therapy".)

More detailed discussions of drug resistance testing and HIV resistance mutations are found in the following topics:

(See "Drug resistance testing in the clinical management of HIV infection".)

(See "Overview of HIV drug resistance testing assays".)


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Literature review current through: Sep 2016. | This topic last updated: May 16, 2016.
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