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Segmental colitis associated with diverticulosis

John H Pemberton, MD
Section Editor
Lawrence S Friedman, MD
Deputy Editor
Shilpa Grover, MD, MPH, AGAF


Patients with diverticular disease can develop a segmental colitis most commonly in the sigmoid colon. The endoscopic and histologic features of segmental colitis associated with diverticulosis (SCAD) or diverticular colitis can range from mild inflammatory changes with submucosal hemorrhages to florid, chronic active inflammation that resembles inflammatory bowel disease [1-8].

This topic review will focus on the pathogenesis, clinical manifestations, diagnosis, and management of SCAD. The epidemiology, risk factors, and the pathogenesis of diverticulosis and diverticular disease and the clinical manifestations, diagnosis, and management of diverticulitis and diverticular bleeding are discussed in detail, separately. (See "Colonic diverticulosis and diverticular disease: Epidemiology, risk factors, and pathogenesis" and "Clinical manifestations and diagnosis of acute diverticulitis in adults" and "Acute colonic diverticulitis: Medical management" and "Colonic diverticular bleeding".)


A diverticulum is a sac-like protrusion of the colonic wall.

Diverticulosis is defined by the presence of diverticula. Diverticulosis may be asymptomatic or symptomatic.

Diverticular disease is defined as clinically significant and symptomatic diverticulosis due to diverticular bleeding, diverticulitis, segmental colitis associated with diverticula, or symptomatic uncomplicated diverticular disease.

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Literature review current through: Oct 2017. | This topic last updated: Sep 06, 2016.
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