Urine collected in a normal individual by suprapubic aspiration of the bladder is sterile and does not contain leukocytes. This method represents the gold standard in the diagnosis of urinary tract infection (UTI) [1,2]. It is, however, not performed routinely in clinical practice. Instead, urine samples are generally obtained after natural micturition; in this setting, some degree of artifactual contamination with normal urethral organisms must be accepted.
This topic discusses the collection and analysis of voided urine for the diagnosis of UTIs in adults. More detailed discussions on acute uncomplicated and complicated UTI in women and men and children are found elsewhere:
●(See "Acute uncomplicated cystitis and pyelonephritis in women".)
●(See "Acute uncomplicated cystitis, pyelonephritis, and asymptomatic bacteriuria in men".)
●(See "Acute complicated cystitis and pyelonephritis".)