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Medline ® Abstract for Reference 80

of 'Safety of infant exposure to antidepressants and benzodiazepines through breastfeeding'

Neonatal benzodiazepines exposure during breastfeeding.
Kelly LE, Poon S, Madadi P, Koren G
J Pediatr. 2012;161(3):448.
OBJECTIVE: To assess central nervous system depression and other adverse effects in infants exposed to benzodiazepines through breast milk.
STUDY DESIGN: A prospectively recruited, retrospectively assessed cohort study of mothers who contacted the Motherisk program regarding the safety of benzodiazepines and were invited to participate in a follow-up program regarding the effects of these medications on their infants during lactation.
RESULTS: A total of 124 consenting women participated. Adverse outcomes, specifically sedation, was identified in only 1.6% (2 of 124) of infants and was not associated with benzodiazepine dose, number of hours breastfed, or any demographic trait. Mothers reporting adverse outcomes in themselves (26% [32 of 124]) were more likely to be taking concomitantly a greater number of central nervous system depressants.
CONCLUSIONS: This study supports the continued recommendation to initiate breastfeeding while taking benzodiazepines postpartum.
Schulich School of Medicine, University of Western Ontario, London, Ontario, Canada.