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Medline ® Abstract for Reference 77

of 'Safety of infant exposure to antidepressants and benzodiazepines through breastfeeding'

77
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Serum clomipramine and metabolite levels in four nursing mother-infant pairs.
AU
Wisner KL, Perel JM, Foglia JP
SO
J Clin Psychiatry. 1995;56(1):17.
 
BACKGROUND: Women with postpartum-onset obsessive compulsive disorder may elect treatment with clomipramine. There is minimal information to guide the clinician who must advise breastfeeding women about clomipramine therapy.
METHOD: Four clomipramine-treated breastfeeding mother-infant pairs were assessed for serum concentrations of clomipramine, N-desmethylclomipramine, and corresponding 8-hydroxymetabolites.
RESULTS: Although the mothers exhibited a wide range of serum concentrations, the parent drug and metabolites were either nondetectable or below the quantifiable limit in the sera of all infants. No adverse clinical effects were observed.
CONCLUSION: This report adds to the growing literature that suggests that tricyclic use during breastfeeding rarely results in measurable drug levels in infant sera.
AD
Mood Disorders Program, Case Western Reserve University, Cleveland, Ohio 44106.
PMID