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Medline ® Abstract for Reference 68

of 'Safety of infant exposure to antidepressants and benzodiazepines through breastfeeding'

68
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Excretion of trazodone in breast milk.
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Verbeeck RK, Ross SG, McKenna EA
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Br J Clin Pharmacol. 1986;22(3):367.
 
The excretion of breast milk was studied in six lactating women following the oral administration of a single trazodone tablet (50 mg). The milk/plasma ratio of trazodone based on area under the plasma and milk curves was small: 0.142 +/- 0.045 (mean +/- s.d.). Assuming that the babies would drink 500 ml 12 h-1, they would be exposed to less than 0.005 mg kg-1 as compared to 0.77 mg kg-1 for the mothers. It is concluded that exposure of babies to trazodone via breast milk is very small.
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PMID