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Risks of bisphosphonate therapy in patients with osteoporosis

Harold N Rosen, MD
Section Editors
Clifford J Rosen, MD
Kenneth E Schmader, MD
Deputy Editor
Jean E Mulder, MD


Osteoporosis is caused by the cumulative effect of bone resorption in excess of bone formation. Bisphosphonates inhibit bone resorption with relatively few side effects. As a result, they are widely used for the prevention and treatment of osteoporosis.

This topic will review the risks of bisphosphonates in patients with osteoporosis. The therapeutic use of bisphosphonates in men and postmenopausal women with osteoporosis, and their side effects in other conditions (such as advanced malignancy), are reviewed separately.

(See "The use of bisphosphonates in postmenopausal women with osteoporosis".)

(See "Treatment of osteoporosis in men", section on 'Pharmacologic therapy'.)

(See "Prevention and treatment of glucocorticoid-induced osteoporosis", section on 'Bisphosphonates'.)


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Literature review current through: Sep 2016. | This topic last updated: Jan 6, 2016.
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