Medline ® Abstract for Reference 92
of 'Risk factors for and possible causes of osteoarthritis'
Predisposition to familial osteoarthrosis linked to type II collagen gene.
Palotie A, Väisänen P, Ott J, Ryhänen L, Elima K, Vikkula M, Cheah K, Vuorio E, Peltonen L
The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.
Laboratory of Molecular Genetics, National Public Health Institute, Helsinki, Finland.